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Thanga Thirupathi, A.
- Wound Healing and Anti Bacterial Activity of the Leaves Extracts of Jasminum grandiflorum Linn
Abstract Views :244 |
PDF Views:1
Authors
T. Raja Sekharan
1,
M. Syam Mohan
2,
P. Natarajan
3,
A. S. William
3,
Arputha Sundar
3,
A. Thanga Thirupathi
3,
R. Venkatnarayanan
4
Affiliations
1 Department of Pharmaceutics , Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
2 UPM Makna Cancer Research Lab, Serdang - 43400, Selangor, MY
3 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
4 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641 402, Tamil Nadu, IN
1 Department of Pharmaceutics , Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
2 UPM Makna Cancer Research Lab, Serdang - 43400, Selangor, MY
3 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
4 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641 402, Tamil Nadu, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 6 (2010), Pagination: 388-391Abstract
Petroleum ether, Chloroform, Ethanol and Aqueous extracts of Jasminum grandiflorum Linn leaves were tested for wound healing and antibacterial activity. Investigation were undertaken to screen the wound healing activity of different extracts of the leaves of Jasminum grandiflorum Linn on excision wound models in albino rats. The aqueous extracts shows significance wound healing activity when compared to the standard (Povidone iodine ointments). Other extract also shows wound healing activity but the wound contraction was less when compared to aqueous extracts and standard. For Salmonella typhi the zone of inhibition for petroleum ether extract is equal and for chloroform extract it is more active compared to that of the standard (Ciprofloxacin disc 5mcg/disc). Ethanolic extract is more active against Staphylococcus aureus than other microorganisms. Aqueous extract is more effective against Streptococcus pyogen and less active against Proteus when compared to the standard.Keywords
Jasminum Grandiflorum Linn; Antibacterial Activity, Wound Healing Activity.
References
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- Sadhu SK, Khan MS, Ohtsuki T and Ishibashi M. Secoiridoids component from Jasminum grandiflorum, Phytochem, 2007, 68: 1718-21.
- Divakar NG, Subramanian V, Sugumaran M and Vaidyanathan CS. Indole oxygenase from the leaves of Jasminum grandiflorum, Plant Science Letter, 1979, 15: 177-180.
- Zhao GQ, Xia JJ and Dong JX. Glycosides from leaves of Jasminum grandiflorum var officinale, Acta Pharmaceutica Sinica, 2007, 42: 1066-9.
- Villegas LF, Fernandez ID, Maldonado H, Torres R, Zavaleta A, Vaisberg AJ and Hammond GB. Evaluation of the woundhealing activity of selected traditional medicinal plants from Peru. J Ethnopharmacol, 1997, 55: 193-200.
- Tsuchiya H Sato M, Miyazaki T, Fujiwara S, Tanigaki S, Ohyama M. et al. Comparative study on the antibacterial activity of phytochemical flavanones against methicillinresistant Staphylococcus aureus. J Ethnopharmacol, 1996, 50: 27-34.
- Studies of Antipyretic and Anti-Inflammatory Activities of Odina woodier Leaves Extracts
Abstract Views :249 |
PDF Views:2
Authors
Affiliations
1 Department of Chemistry, SFR College for women, Sivakasi, Tamil Nadu, IN
2 Department of Chemistry, SFR College for women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN
1 Department of Chemistry, SFR College for women, Sivakasi, Tamil Nadu, IN
2 Department of Chemistry, SFR College for women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 5 (2011), Pagination: 263-267Abstract
Antipyretic and anti-inflammatory activities of different extracts of Odina woodier leaves were studied by observing decrease in rectal temperature and reduction in paw edema using albino rats of both sexes. Animals were divided into ten groups, each consisting of six animals. Group 1 served as control and Group 2 received the standard drug. Group 3-10 received various extracts of Odina woodier leaves. Group 3 received ethanol extracts of 200mg/kg and Group 4 received 400mg/kg. Group 5 and Group 6 received ethyl acetate extracts of 200mg/kg and 400mg/kg respectively. Similarly Group 7 and Group 8 received chloroform extracts of 200mg/kg and 400mg/kg. Group 9 received 200mg/kg and Group 10 received 400mg/kg petroleum ether extracts of Odina woodier leaves. For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension and for anti-inflammatory activity, inflammation was induced using 1% carageenan suspension. The results showed that all the extracts were found to have both antipyretic and anti-inflammatory activities. Among these four extracts, ethanol extract of 400 mg/kg have shown same antipyretic activity after four hours of drug administration as that of the standard Paracetamol drug which caused the reduction of temperature of 1.03 and 1.02 for the extracts and Paracetamol drug . 400mg/kg of ethyl acetate extract after two hours have shown higher anti-inflammatory activity (40.43%) with a probability < 0.001 than the chosen standard drug diclofenac sodium(39.75%) available as an anti-inflammatory drug in the market.Keywords
Antipyretic, Anti-Inflammatory, Carageenan, Pyrexia and Odina Woodier.References
- Kiritikar, K.R. and Basu, B.D. Indian Medicinal Plants, 1935, 2nd Edition, International Book Distributors, Book Sellers and Publishers, Dehradun.
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- Kiritikar, K.R. and Basu, B.D. (1987) Indian Medicinal Plants, International Book Distributors, Book Sellers and Publishers, Dehradun.
- Ramakrishnan,P.N., Palanichamy,S(2004). Extraction and Galenicals/Pharmaceutics-1Ed.9, Jai publishers, Madurai.PP.82-85.
- Niazi J, Vikas Gupta V, Chakarborty P,Kumar P; Anti-inflammatory and antipyretic activity of aleuritis moluccana leaves .Asian Journal of Pharmaceutical and Clinical Research , 2010, Vol.3 Issue 1, January-March 35-37.
- Vogel H.G. ”Drug discovery and evaluation”,2nd edition,772.
- Hajare S W, Chandra S, Tandan S. K., Sharma J, Lal J,Telang A G; Analgesic and antipyretic activity of Dalbergia Sissoo Leaves. Indian Journal of Pharmacology 2000, 32, 357-360.
- Cheng L, Ming-liang H, Lars B et al. Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. Acta Pharmacologica Sinica 2005, 26, 926-933.
- Brownlee.G.(1937). A comparison of the antipyretic activity and toxicity of Phenacetin and aspirin. Journal of Pharmacy and Pharmacology.10:609-611.
- Asha.V.V., Pushpangadhan, P(1999). Antipyretic activity of Cardiospermum halicacabum Linn. Indian journal of Experimental biology.37(4):411-414.s
- Winter CA, Risley EA, Nuss CW. Carrageenan induced edema in hind paw of rat as an assay for anti-inflammatory drugs. In: Proc. Soc. Exp. Biol. Med. 1962, 11,544-547.
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- Analgesic, Antipyretic, CNS and PASS Prediction Activities of 4-(4-Hydroxy Benzylidene Amino) Phenol Schiff Base
Abstract Views :182 |
PDF Views:0
Authors
Affiliations
1 S.F.R. College for Women, Sivakasi, Viruthunagar District, Tamil Nadu, IN
2 Department of Chemistry, S.F.R College for Women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN
1 S.F.R. College for Women, Sivakasi, Viruthunagar District, Tamil Nadu, IN
2 Department of Chemistry, S.F.R College for Women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN
Source
Research Journal of Science and Technology, Vol 4, No 5 (2012), Pagination: 192-196Abstract
The Schiff base 4-(4-hydroxy benzylidene amino)phenol was prepared from p-hydroxybenzaldehyde and 4-aminophenol by condensation method using standard procedure. Analgesic, antipyretic and CNS activities of 4-(4- hydroxy benzylidene amino) phenol Schiff base were studied using albino rats of both the sexes. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 4-(4-hydroxy benzylidene amino) phenol. For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension. The analgesic activity was determined by tail immersion method. CNS depressant activity of the compound was measured by placing the rat individually in the actophotometer for 10 min. The results obtained showed that the Schiff base was found to exhibit analgesic, antipyretic and CNS activities. The analgesic activity of the Schiff base compared to the standard drug pentazocine was found to be higher in the first hour and then the activity decreases slowly. The reduction in the rectal temperature for this compound was observed to be less than the standard drug paracetamol. 4-(4-hydroxy benzylidene amino)phenol Schiff base of 250mg/kg possessed CNS stimulant activity with a probability <0.001. 4-(4-hydroxy benzylidene amino)phenol Schiff base was found to possess highest glutathione thiolesterase inhibitor activity as 86% and other activities greater than 80% as per the prediction using PASS (online bioactivity prediction software) .Keywords
P-Hydroxybenzaldehyde, 4-Aminophenol, Analgesic, Antipyretic , CNS and PASS.- Pharmacognostical and Preliminary Phytochemical Screening the Leaves of Jasminum grandiflorum Linn
Abstract Views :149 |
PDF Views:0
Authors
Affiliations
1 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
2 UPM, Makna Cancer Research Lab, Serdang – 43400, Selangor, MY
3 RVS college of Pharmaceutical Sciences, Sulur, Coimbatore-641 402, IN
4 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
1 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
2 UPM, Makna Cancer Research Lab, Serdang – 43400, Selangor, MY
3 RVS college of Pharmaceutical Sciences, Sulur, Coimbatore-641 402, IN
4 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN